analytical-method-validation agent skill by K-Dense-AI

At a glance

Before you install

Read from the skill's files at the directory's October 19, 2026 snapshot: what ships with it, what its code reads, and the terms it is published under.

• Bundled scripts: 8 script files (8 Python). Your agent may run them, so read them first.
• Tool permissions requested: Read Write Edit Bash (the allowed-tools field of SKILL.md).
• License: MIT, an open-source or open-content license.

Install analytical-method-validation

The skills CLI works with Claude Code, Codex, Cursor and other agents; the other routes copy the folder by hand.

npx skills add https://github.com/K-Dense-AI/claude-scientific-skills/tree/main/skills/analytical-method-validation

tmp="$(mktemp -d)"
git clone --depth 1 https://github.com/K-Dense-AI/claude-scientific-skills.git "$tmp/repo"
mkdir -p .claude/skills
cp -R "$tmp/repo/"skills/analytical-method-validation .claude/skills/
rm -rf "$tmp"

python3 ~/.codex/skills/.system/skill-installer/scripts/install-skill-from-github.py \
    --repo K-Dense-AI/claude-scientific-skills \
    --path skills/analytical-method-validation

K-Dense-AI/claude-scientific-skills is third-party code. Read SKILL.md and any bundled scripts before you install it.

How the author describes it

Plans, executes, and documents validation, verification, and transfer of analytical procedures under the governing framework - ICH Q2(R2) and Q14, USP <1220>/<1225>/<1226>, ICH M10 bioanalytical, CLSI EP, or ISO/IEC 17025. Use for HPLC, LC-MS/MS, GC, CE, ICP-MS, dissolution, qNMR, qPCR, NIR, and ligand binding or cell-based assays whenever the question is whether a procedure is fit for its intended purpose. Triggers include "method validation", "analytical method validation", "AMV", "validation protocol", "acceptance criteria", "linearity", "reportable range", "accuracy and precision", "repeatability", "intermediate precision", "recovery", "LOD", "LOQ", "detection limit", "quantitation limit", "specificity", "robustness", "method transfer", "method comparison", "Deming", "Passing-Bablok", "Bland-Altman", "equivalence testing", "OOS investigation", "ICH Q2", "Q2(R2)", "Q14", "USP 1225", "ICH M10", "incurred sample reanalysis", "ISR", "CLSI EP", and any request to show that an assay works.

From the description field of SKILL.md. Agents read this line to decide when to load the skill.

Compatibility, from SKILL.md

Sections in SKILL.md

• When to use
• The two rules
• Scope
• Copyright boundary
• Frameworks
• Scripts
• Workflow
• 1. Fix the framework and the required characteristics
• 2. Generate the protocol and fill in the criteria
• 3. Evaluate the response
• 4. Evaluate accuracy and precision
• 5. Establish DL and QL, and confirm them
• 6. Bioanalytical runs under ICH M10
• 7. Transfer and method comparison
• What this skill exists to prevent
• References

Files in the skill folder

• SKILL.md
• assets/validation-protocol-template.md
• assets/validation-report-template.md
• references/compendial-and-clsi.md
• references/framework-selection.md
• references/ich-m10-bioanalytical.md
• references/ich-q2r2.md
• references/source-ledger.md
• references/statistics.md
• scripts/_catalog.py
• scripts/_common.py
• scripts/check_accuracy_precision.py
• scripts/check_bioanalytical_run.py
• scripts/check_detection_limits.py
• scripts/check_response.py
• scripts/compare_methods.py
• scripts/plan_validation.py

Suede Skill Check: 88/100 · B

analytical-method-validation passes the required frontmatter check and all seven graded checks, which cover the SKILL.md format, a declared license and a commit in the last year. Those checks earn 56 of the score’s points; the rest come from description quality, instruction depth, bundled files, maintenance and curated-list citations. How the score works.

Where this skill is cited

K-Dense-AI/claude-scientific-skills appears in 2 curated lists: BehiSecc/awesome-claude-skills, travisvn/awesome-claude-skills.

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